In a 5 page paper(excluding title page and references), evaluate the study according to research design methods, procedures and study results, for example, see Evaluating a quantitative study Use chapter 8 in LoBiondo-Wood, G., & Haber, J. (2018). Nursing research: Methods and critical appraisal for evidence-based practice.(9th ed) St. Louis, MO: Elsevier. To assist you with this assignment.
Include a discussion on how the study contributes to evidence-based practice (EBP).
Pick one of the two following research articles to complete your assignment:
Study 1 – Patients’ and partners’ health-related quality of life before and 4 months after coronary artery bypass grafting surgery
Study 2 – Striving for independence: a qualitative study of women living with vertebral fracture
A total of 295 patients were analysed for the previous drug intakes using case record form (CRF) information; 21.1% patients did not took drug, 75.4% patients were not aware about previous intake and 3.5% of the patients were in category where information was not recorded. However, blood samples were analysed on day 0 by HPLC, 24.2 % patients had residual antimalarial. Rarasite density with residual CQ: Parasitemia was compared between patients had residual antimalarials (n=27) on day 0; 1056 to 78240 asexual parasites/”l (mean ”SD: 20394”19735 asexual parasites/”l) and with patients not having residual CQ on day 0 (n=262), that is, 616 to 99290 asexual parasites/”l (mean” SD: 23687”25835 asexual parasites/”l). Low level of residual CQ in those samples which had higher parasite density per microliter of blood and vice versa. Parasite density with residual SDX: Parasitemia was compared between patients had residual SDX in (n=49) on day 0; 1154 to 80238 asexual parasites/”l (mean ”SD: 16733”18077asexual parasites/”l, P<0.05**) and those with no SDX on day 0 (n=240), that is, 616 to 99290 asexual parasites/”l (mean” SD: 25023”26665asexual parasites/”l, P<0.05**). Low level of residual SDX in those samples which had higher parasite density per microliter of blood and vice versa Molecular markers of drug resistance Pfdhfr: To monitor the PYR drug resistance in collected 295 samples, out of these samples, 288 samples could be amplified for dhfr and dhps both gene. In dhfr gene, double mutation was observed highest frequency (71.9%) followed by single (9%) and triples (2.4%) mutation and 16.7% samples had wild type genotype. Frequency of double mutation (59+108) was higher in Madhya Pradesh (97.5%) followed by Chhattisgarh (75.4%), Jharkhand (64.8%) and Odisha (46.5%) of the samples. Single mutation was seen 18.3%, 12.7%, 3% and 2.5% in Odisha, Jharkhand, Chhattisgarh and Madhya Pradesh samples, respectively. Triple mutation was observed in 9.1% isolate in Chhattisgarh and only 1.4% isolates from Jharkhand. While wild genotype was observed in highest frequency (35.2%) in Odisha followed by Jharkhand (21.1%) and Chhattisgarh isolates (12.1%).>GET ANSWER