The nature of criminality is a central idea in detective fiction. Detective stories and novels consistently focus on causes and propensities for criminal behavior, as the detective uses various theories and observations of human motivation to solve a crime. Using The Murder of Roger Ackroyd and ONE of the following other detective stories we have discussed thus far in class (“The Adventure of the Speckled Band” or “The Murder in the Rue Morgue”) argue how human weakness is portrayed as the source of criminality, and how this knowledge helps the fictional detectives solve the mysteries.
skeletal muscle strength and endurance function and structure (fiber size, fiber type distribution, capillary density, and metabolic capacity) (Zeng et al., 2018). A prolonged lack of exercise promotes a decrease in physical activity in COPD sufferers. The activity of these muscles rely greatly on the physiologic structural elements of the particular muscle and the velocity at which a fiber contracts inversely regulates the fibers ability t resist fatigue. Type I fibers are slow-twitch fibers and can endure long periods of exercise as they are highly resistant to fatigue. They are comprised of myosin heavy-chain (MyHC) type I. Type IIx fibers are fast-twitch fibers and are a subset or the fast twitch muscles which contain type IIa and type IIb. Type IIx fibers are the strongest and lowest endurance abibity as they fatigue much easier. Their composition differs from Type I fibers as they are composed of MyHC type IIx. It has been reported that a less than 27% of fiber type I proportionality is regarded as unusually low. Additionally, an amount of fiber type IIX that is greater than 29% is regarded as unusually large (Barreiro and Gea, 2016). In cases where the subject suffers from COPD, the amount of type I fibers are significantly lower than that of a healthy individual. Also a greater amount of type IIb fibers are present, thus demonstrating why COPD sufferers possess greater muscular fatigability and a lack of endurability (Whittom et al., 1998). Muscle dysfunction and wastage are major systemic manifestations in COPD. Patients’ respiratory and limb muscles are often impaired and this adds to defective muscle function, low exercise ability and poorer health in general. Diminishing muscle fiber cross-sectional area is largely an accepted distinguisher of muscle atrophy and may be an indication of mortality associated with COPD (Gouzi et al., 2013). Hyperinflation is another crucial aspect of COPD as hyperinflated lungs may lead to consequential destructive breathing issues. This is displayed by advancements in COPD symptoms following lung volume reduction surgery. Static and dynamic processes may both lead to hyperinflation in COPD, static being caused by a decline in elasticity as a result of emphysema. Dynamic hyperinflation is as a result of exercise and is found present more frequently and is caused by air becoming trapped in the lungs as a result of an imbalance in the volumes of air inhaled and exhaled (Ferguson, 2006). Inadequate exhalation generates continuous air retention referred to as ‘air trapping’, consequently leading to dyspnea (O’Donnell and Laveneziana, 2006). TREATMENT & CURE: There is currently no cure for COPD however patients affected by this disease can take steps to slow down its progression. The main one being smoking cessation. Lung function stabilizes after smoking cessation and will decline at a much slower rate. If one is a successive smoker, lung function declines more rapidly. The earlier the detection and diagnosis of the disease, the earlier treatment can commence and suitable treatment varies from patient to patient as it has to consider the severity of their symptoms. Bronchodilators and anti-inflammatory medication help improve the performance of the lungs and reduce the likelihood of developing exasperations. In more sever cases surgical procedures may be the best option to help increase patients’ quality of life. Pulmonary rehabilitation is the main factor>GET ANSWER