Discuss how age affects medication therapy and dosing considerations. The response should be based on peer reviewed scholarly journals and textbooks, not websites such as Wikipedia, Google, etc.
esponse of just 35% for radiation alone (Excellus BCBS). Tumor Treating Field Therapy Another therapy that is not well known is tumor treating field (TTF) therapy. Tumor treating field therapy is the use of electrical fields to disrupt rapidly dividing cancerous cells (Hopkins Medicine). The electric field acts on charged proteins, such as tubulin and septin, in the cells that are important for mitosis, cell division (Novocure). It specifically stops the cell from forming chains that separate genetic material in the cell’s nucleus and the correct positioning of these charged proteins before cell division (Hopkins Medicine). When cells cannot divide normally, they go through a process called apoptosis, cell death. History The conception of tumor treating field therapy started with an Israeli man named Dr. Yoram Palti. He wanted to explore how electric fields can treat tumors and explored this idea in his basement in 2000 and soon opened up a research center in Haifa, Israel in 2002. After coming up with the idea and forming his company, Novocure, the first pilot trial was performed in Prague, Czech Republic in 2004. After initial promise, trials were then started across the United States, European Union, and Israel in 2006 to test TTF versus chemotherapy in the treatment of recurrent glioblastoma. Another trial started in 2009 and moved to focus on and treat newly diagnosed glioblastomas. This new trial treated patients who had already received surgery and radiation with TTF and also included using temozolomide, a chemotherapy drug used for treating glioblastoma multiforme (The Oncologist). When the first trial proved TTF to be a successful treatment in 2011, the FDA approved TTF under the name “Optune” for the treatment of recurrent glioblastoma. When the 2009 trial proved even better results, the FDA approved “Optune” to treat newly diagnosed glioblastoma. Since then, Novocure has created even more trials for different types of cancer and has even been able to optimize their system to create a smaller therapy delivering device. At this moment they have trials for brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer, liver cancer, and mesothelioma. Not only do they currently have ongoing clinical trials for many different cancers, they even have pre-clinical trials set for a very extensive list of other serious types of cancer like breast cancer, cervical cancer, and malignant melanoma to name a few. The Optune treatment can be found in the United States, Germany, Austria, Switzerland, Israel, and Japan.>GET ANSWER