Write a financial statement analysis on Johnson & Johnson company comparing 5 years of segment of Johnson & Johnson financial statement showing the increase and decrease of each year and the reason why it increase or decrease. For example why year 2013 is lower or higher than 2014. I also want the company 5 categories of financial ratio. Please include income statement, balance sheet, and cash flow. Please include graph and picture.
Viability of development factors focus (hGH, IGF-1, FGF-2, PDGF, VEGF) after autologous Platelet-rich plasma infusion (PRP) on quickening mending of proximal hamstring tear for competitors. Ahmed Gaballah 1-Department of Sports Health Sciences, Damietta University, Damietta, Egypt. 2-Kinesiology and Health Sciences Department, Utah State University, Logan, UT, USA Conceptual Platelet rich plasma (PRP) end up prominent naturally technique used to quicken recuperating in games medication and orthopedic medical procedure field. PRP is think the human platelets to supra-physiologic levels. It is an autologous delivering abnormal state of the platelets fixation centrifuged from the fringe vein. At that point it re-infused under the ultrasound affectedness amid medical procedure or at a site of damage. Technique: Seventeen physically dynamic guys (age 22.0±0.6) with intense hamstring strain wounds separated to 8 case gathering and 9 coordinated controls (age 21.6±2.8) were enrolled as research members. Case assemble members were infused with single 3 ml of extricated PRP under ultrasound pomposity. In any case, Blood tests were gathered by venipuncture at institutionalized time focuses: before the infusion and 24, 48, 72, and 96 hours after for case gathering and 4wks. what's more, 8wks for the two gatherings. RESULTS: there was essentially distinction between the development factors consequences of the case bunch following a month contrasted and the two months aftereffect of the control gathering. Also, the equivalent critical outcomes between the two gatherings after the two months. All things considered, the physical estimations related with hamstring Strain and Knee flexion scope of movement between the two gatherings were not noteworthy following a month or two months. CONCLUTION: a solitary 3-mL infusion of autologous PRP joined with a recovery program was powerful in time come back to play and lessening the seriousness of agony after an intense review 2 hamstring damage. Also, increment in coursing convergences of VEGF, IGF-1, PDGF and FGF-2. Watchwords: Platelet rich plasma (PRP), Human Growth Factors, Hamstring Tear. 1. Presentation: Skeletal muscle wounds are up to 55% of all games wounds and causes unreasonable long haul torment and physical inability, Muscles strains and wounds speaking to over 90% of all games related wounds and are the most strong wounds visit.   Proximal hamstring tear wounds are basic in competitors and as often as possible outcome in drawn out restoration, time missed from play, and a noteworthy danger of re-damage. Reports of intense hamstring strains without separation in artists have recommended recuperation times for come back to-play going from 30 to 76 weeks . Platelet rich plasma (PRP) wind up prominent naturally technique used to quicken mending in games prescription and orthopedic medical procedure field. PRP is think the human platelets to supra-physiologic levels. It is an autologous delivering abnormal state of the platelets fixation centrifuged from the fringe vein. At that point it re-infused under the ultrasound ostentatiousness amid medical procedure or at a site of damage  . Because of the need reaction and the autologous idea of PRP, it has used exponentially in the course of the most recent couple of years in games prescription and orthopedic. Generally, since the 1950s the platelet-rich plasma (PRP) has been utilized to dermatological conditions and oversee maxillofacial too . Moreover, Platelet-inferred arrangements including PRP were first managed by WADA under the 2010 Prohibited List due to worries that the lifted convergences of development factors in PRP may give an uncalled for preferred standpoint to treated competitors. Nonetheless, WADA lifted the prohibition on PRP in 2011 in acknowledgment of the absence of proof to help a fundamental execution improving impact and to permit additionally look into in the field . To be sure, the blood contains 6% platelets, 1% white platelets, and 93% red platelets. The PRP method intends to switch the centralization of the platelet in lieu of red cells to expand the development factors that more helpful in quickening the mending.  However, Platelet rich plasma (PRP) is a centrifuged blood item that contains a supraphysiologic measure of platelets. Subsequently, the arrangement procedure to item concentrative platelet over the benchmark esteems have begun with an autologous extraction of patients` blood, at that point by plasmapheresis centrifuged to get a concentrated suspension of platelets. It at that point isolates the strong and fluid segments of the anticoagulated blood after a two-phase of centrifugation process . The underlying stage isolates the plasma and platelets from the erythrocytes and leucocytes. The second stage thinks the platelets facilitate into platelet-rich and platelet-poor plasma segments  . Platelet rich plasma (PRP) contains some biologic elements which have been upgraded the expansion and collagen emission of tenocytes. These components including vascular endothelial development factor (VEGF), fundamental fibroblast development factor (FGF2), and changing development factor β (TGF β)  . There is an expanding the improvement reaction of PDGF and TGF-β in the beginning times of ligament and muscles mending after PRP infusion bringing about new vessel development and collagen amalgamation. . Notwithstanding diminish oxidative pressure that could prompt cell apoptosis, PRP has been advanced ligament and muscles cell development . This is confirm and fortified by arrival of incendiary meiators, for example, COX-1 and2, PGE-2  . As of late, there are different methodologies announced the advantages of treating the delicate tissue wounds, for example, muscles tears and tendinosis by infusing platelet rich plasma (PRP). Notwithstanding this advancement and expanding use in delicate tissue wounds, its viability still not clear and stays dubious. It has been already settled that platelets give regenerative potential by the procedure of chemo-taxis   . The utilization of PRP with the end goal to quicken recuperation time after muscle damage has turned into a moderately regular practice in games prescription. A few investigations speak to that PRP can enhance skeletal muscle recuperating after intense damage. Specifically, nearby PRP which expanded articulation of a few myogenic factors at mRNA level following up on modlating the fiery reaction and myogenesis in the beginning times after intense damage  . Rossi L, et al. revealed the impacts of an autologous PRP infusions on time to come back to play in randomized controlled examination led on 75 patients. The investigation spoken to time to come back to play for recreational and focused competitors and repeat rate after intense muscle wounds also. The primary outcome in the examination that PRP infusion noteworthy decrease of re-damage rates at 2 years. Moreover, it was diminished the agony seriousness score and fundamentally diminished the season of come back to sports also . One more examination announced that 14 proficient competitors were treated with ultrasound-direction infusions of PRP after intense muscle wounds. The competitors demonstrated a fast come back to movement and enhanced recuperating in muscle tears . Comparative outcomes have spoken to in Sanchez et al consider, which led on 20 competitors. These outcomes upheld the advantages of PRP and its job in muscle mending. The patients recuperated in half of the normal time .>GET ANSWER