Based on the case, provide recommendations that stated directly, carefully, and clearly.
Give reasonable explanation and provide clear and complete support for the recommendation, reflects good or deep insight to the case.
One of the recommendations can analyze the bottleneck that refers to lowest effective capacity of any process. (Related questions: What is the bottleneck in the production? How can you alleviate bottleneck?)
Particle size of Eudragit S100 and HPMC Phthalate HP55 nanoparticles was directly proportional to polymer concentration (Eudragit S100 and HPMC Phthalate HP55 concentration respectively) as the particles size increased with increasing polymer concentration [211, 212] and this may be due to increasing the concentration of dissolved polymer resulted in increasing organic phase viscosity and reducing the efficiency of stirring which caused formation of the bigger emulsion droplets  and this can be also attributed to that higher viscosity that is predictable to increase polymer – polymer and polymer-solvent interactions [147, 214]. When polymer concentration in the case of Eudragit S100 and HPMC Phthalate HP55 was increased from 0.2 gm% to 0.8 gm% with Tween 80 concentration of 0.5% w/v and phase ratio of (1:2), particle size was increased from 390±9.4634 to 714±2.0548 and from 434±3.0912 to 863±0.9428 nm respectively. The same effect of polymer concentration on particle size was the same either in the case of increasing Tween 80 concentration and /or increasing the phase ratio as shown in the tables (4, 6 and 8) and figures (3, 5 and 7). When polymer concentration in the case of Eudragit S100 and HPMC Phthalate HP55 was increased from 0.2 gm% to 0.8 gm% with Poloxamer 407 concentration of 0.5% w/v and phase ratio of (1:2), particle size was increased from 404±8.6538 to 747±1.6997 and from 598±1.633 to 905±4.0277 nm respectively. The same effect of polymer concentration on particle size was the same either in the case of increasing Poloxamer 407 concentration and / or increasing the phase ratio as shown in the tables (5, 7 and 9) and figures (4, 6 and 8). These results were found to agree with the results of both Galindo-Rodriguez et al., 2004  who prepared nanoparticles of Eudragit L100-55 using nanoprecipitation method to determine effect of polymer concentration on nanoparticle size using different organic solvents and he found that in all cases, increasing polymer concentration in organic phase resulted in increasing mean size ,and D. Quintanar-Guerrero et al., 1999  who used emulsion-diffusion method to prepare Eudragit E nanoparticles using Eudragit E/ethyl acetate/PVAL system and cellulose acetate phthalate (CAP) nanoparticles using cellulose acetate phthalate/2-butanone/Poloxamer 407 system and in two systems it was found that there is a switch between micro and nanoparticles depending on polymer concentration in internal organic phase where, as polymer concentration increased, size of produced particles significantly increased . On the other hand, these results are disagreeing with those reported in Ahmed, I.S., et al.,2014  who prepared poly-Ɛ- caprolactone nanoparticles by solvent displacement method and investigated the effect of polymer concentration on particle size. It was found that increasing polymer concentration from (0.5 to 0.8% w/v) at surfactant concentration (0.5% w/v) resulted in increasing particle size while, at the same surfactant concentration and increasing polymer concentration to (1% w/v) >GET ANSWER