1. Explain the biochemical absorption, storage and metabolic function of macro and micronutrients. 2. Describe the role of nutrients in the optimal functioning of key biochemical pathways in the body. 3. Integrate biochemical mechanisms with disease pathology and clinical treatment options. TASK: Five short answer application questions. Carefully analyse the case history provided and answer each of the five questions below. Each answer should be approximately 300 words. Ensure that you cover the nutritional biochemical mechanisms and role of nutrients in each answer. Use the template provided to build your answer. Case study Mrs Smith, a 45 years old female, presents at a holistic nutrition clinic with the classic symptoms of irritable bowel syndrome (IBS) including bloating, gas (flatulence), abdominal cramping, and diarrhoea. She has high blood pressure and is pre-diabetic. She also complains of feeling weak and lethargic after diagnosis of her pre diabetes. She is anxious as has just accepted a new job. Her recent blood pathology results indicate elevated liver enzymes. She takes his Zantac regularly for IBS symptoms prescribed by his GP. Her job role is highly demanding and involves night shift. This has greatly affected her dietary habits. She mainly relies on junk/ready to eat food. These foods are typically high in sugar and fat. She drinks 3-4 glass of wine before bed and about 8-10 cups of coffee throughout the day. Past History: Helicobacter pylori Family history: Father: Hypertension and Atherosclerosis

Questions: 1. 1. Discuss the role of prebiotics and probiotics for this patient in the management of IBS (16 marks). Define Probiotics and prebiotics with examples of foods and supplements Mechanisms Through which both probiotics and prebiotics interact with human biochemical pathways (focusing on client’s IBS, anxiety, gut health) Four Benefits of consumption For Mrs Smith condition Any caution for consumption For Mrs Smith condition Your nutritional advice for Mrs Smith for probiotic and prebiotic consumption Give rationale with the support of research evidence focusing on holistic nutritional treatment

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