Patients with graft failure at one year.

  1. Identify the following variables from the following publications (20 marks).
    Variables
    a. Population
    b. Intervention
    c. Control
    d. Primary outcomes
    e. Secondary outcomes
    Publications
    a. https://www.ncbi.nlm.nih.gov/pubmed/30538796
    b. https://www.ncbi.nlm.nih.gov/pubmed/30463577
    c. https://www.ncbi.nlm.nih.gov/pubmed/30412065
  2. Indicate whether the primary outcomes in each of the publications that you identified in
    question 1 are appropriate. Justify each of your answers in a maximum of 300 words (15
    marks).
  3. A systematic reviewer performs a systematic review in which only English articles from
    MEDLINE and EMBASE are searched. Is this appropriate? Justify your answer in a maximum
    of 200 words (5 marks).
  4. What is the Boolean operator used in the following situations? Justify your answer in
    maximum of 200 words for both questions (5 marks).
    a. Combine free text and controlled vocabulary terms for the domain ‘stroke’.
    b. Combine the domains ‘rehabilitation’ and ‘stroke’ in order to identify only articles
    which contain both these domains.
  5. Classify the following as different types of outcomes (binary, continuous, ordinal, count,
    time-to-event outcomes) (5 marks).
    a. Number of patients with graft failure at one year.
    b. Change in SF-36 (health-related quality of life score) in 6 months.
    c. Number of pain episodes in 3 months.
    d. Length of intensive care unit stay (days).
    e. Overall survival at maximal follow-up.
    SURG0098_CW_2: Total marks: 50
    Notes/Instructions (in addition to the general instructions available in the assignment instructions):
    a. You are a systematic reviewer performing systematic reviews on the intervention versus
    control in the population specified in the individual study. The outcomes for this systematic
    review are listed for each study. As in real life, you will find that information may be fully
    available in a study, partially available, in which case please indicate any partially available
    information (indicating clearly that the information is not sufficient for meta-analysis), or
    may not be available at all, in which case, please indicate clearly that the information is
    missing completely.
    b. All comparisons are intervention versus control unless specified.
    c. ‘Appropriate format’ indicates format appropriate for conducting a meta-analysis. This also
    means that you have to identify clearly whether the data extracted is for analysis as binary
    outcome, continuous outcome, count outcome, or time-to-event outcome.
    d. Validated scale means that this should be validated independently in a different study (i.e.
    external validation).
    e. Choose the most appropriate analysis that should be used to decide whether someone
    should receive intervention or control. Marks will be reduced for reporting inappropriate
    analysis.
  6. Comparison of different chemotherapy agents in the treatment of advanced or metastastic
    gastric cancer (25 marks)
    a. Outcomes:
    i. Overall survival
    ii. Proportion of people with serious adverse events
    iii. Number of serious adverse events
    iv. Health-related quality of life (using a validated scale)
    v. Progression-free survival
    vi. Proportion of people with any adverse event (includes all adverse events of
    any severity)
    vii. Number of adverse events
    b. Timing of outcomes: survival outcomes and health-related quality of life – until
    maximum follow-up, others at the end of the treatment or within 3 months after the
    end of the treatment)
    c. Publications
    i. https://www.ncbi.nlm.nih.gov/pubmed/29488121
    ii. https://www.ncbi.nlm.nih.gov/pubmed/27764906
  7. Comparison of different methods to improve outcomes in the treatment of acute myocardial
    infarction (25 marks)
    a. Outcomes:
    i. Overall survival
    ii. Proportion of people with serious adverse events
    iii. Number of serious adverse events
    iv. Health-related quality of life (using a validated scale)
    v. Recurrent heart attacks
    vi. Proportion of people with any adverse event (includes all adverse events of
    any severity)
    vii. Number of adverse events
    b. Timing of outcomes: survival, health-related quality of life, recurrent heart attack –
    until maximum follow-up, others at the end of the treatment or within 3 months
    after the end of the treatment)
    c. Publications
    i. https://www.ncbi.nlm.nih.gov/pubmed/29869460
    ii. https://www.ncbi.nlm.nih.gov/pubmed/28682422

Sample Solution

ACED ESSAYS