- Why are high density lipoproteins (HDLs) considered the “good cholesterol”? In your answer explain specifically what HDLs do that cause it to be considered the “good cholesterol”.
- Why are low density lipoproteins (LDLs) considered the “bad cholesterol”? In your answer explain specifically what LDLs do that cause it to be considered the “bad cholesterol”.
- What is the role of the phospholipid monolayer at the outer surface of lipoprotein particles? (Question 1 of case study)
- Why are cholesterol, cholesteryl esters, and triglycerides preferentially contained inside lipoprotein particles? (Question 2 of case study)
- What are the two sources of cholesterol in the human body?
- What is a “committed step” in a biochemical pathway? (Question 3 of case study)
- Looking at Figure 4 of case study (the reaction pathway from acetyl-CoA), which enzyme is likely to be the target of the statin mevastatin? (Question 6 of case study)
- What are four (4) ways that HDL levels can be increased in the body?
- What type of inhibitor (non-competitive OR competitive) are statins with respect to HMG-CoA reductase enzyme activity? Explain why.
- How were cholesterol-lowering statin drugs first discovered?
