Write a Cancer Review paper covering one of the recommended topic related to current cancer research.
Recommended topic:
Role of stomach bacteria in the development of
cancer – The Human Microbiome
Gao R, Gao Z, Huang L, Qin H. Gut microbiota and colorectal cancer. Eur J Clin
Microbiol Infect Dis. 2017 Jan 7. doi: 10.1007/s10096-016-2881-8. Review. PubMed
PMID: 28063002.
Sample solution
Dante Alighieri played a critical role in the literature world through his poem Divine Comedy that was written in the 14th century. The poem contains Inferno, Purgatorio, and Paradiso. The Inferno is a description of the nine circles of torment that are found on the earth. It depicts the realms of the people that have gone against the spiritual values and who, instead, have chosen bestial appetite, violence, or fraud and malice. The nine circles of hell are limbo, lust, gluttony, greed and wrath. Others are heresy, violence, fraud, and treachery. The purpose of this paper is to examine the Dante’s Inferno in the perspective of its portrayal of God’s image and the justification of hell.
In this epic poem, God is portrayed as a super being guilty of multiple weaknesses including being egotistic, unjust, and hypocritical. Dante, in this poem, depicts God as being more human than divine by challenging God’s omnipotence. Additionally, the manner in which Dante describes Hell is in full contradiction to the morals of God as written in the Bible. When god arranges Hell to flatter Himself, He commits egotism, a sin that is common among human beings (Cheney, 2016). The weakness is depicted in Limbo and on the Gate of Hell where, for instance, God sends those who do not worship Him to Hell. This implies that failure to worship Him is a sin.
God is also depicted as lacking justice in His actions thus removing the godly image. The injustice is portrayed by the manner in which the sodomites and opportunists are treated. The opportunists are subjected to banner chasing in their lives after death followed by being stung by insects and maggots. They are known to having done neither good nor bad during their lifetimes and, therefore, justice could have demanded that they be granted a neutral punishment having lived a neutral life. The sodomites are also punished unfairly by God when Brunetto Lattini is condemned to hell despite being a good leader (Babor, T. F., McGovern, T., & Robaina, K. (2017). While he commited sodomy, God chooses to ignore all the other good deeds that Brunetto did.
Finally, God is also portrayed as being hypocritical in His actions, a sin that further diminishes His godliness and makes Him more human. A case in point is when God condemns the sin of egotism and goes ahead to commit it repeatedly. Proverbs 29:23 states that “arrogance will bring your downfall, but if you are humble, you will be respected.” When Slattery condemns Dante’s human state as being weak, doubtful, and limited, he is proving God’s hypocrisy because He is also human (Verdicchio, 2015). The actions of God in Hell as portrayed by Dante are inconsistent with the Biblical literature. Both Dante and God are prone to making mistakes, something common among human beings thus making God more human.
To wrap it up, Dante portrays God is more human since He commits the same sins that humans commit: egotism, hypocrisy, and injustice. Hell is justified as being a destination for victims of the mistakes committed by God. The Hell is presented as being a totally different place as compared to what is written about it in the Bible. As a result, reading through the text gives an image of God who is prone to the very mistakes common to humans thus ripping Him off His lofty status of divine and, instead, making Him a mere human. Whether or not Dante did it intentionally is subject to debate but one thing is clear in the poem: the misconstrued notion of God is revealed to future generations.
References
Babor, T. F., McGovern, T., & Robaina, K. (2017). Dante’s inferno: Seven deadly sins in scientific publishing and how to avoid them. Addiction Science: A Guide for the Perplexed, 267.
Cheney, L. D. G. (2016). Illustrations for Dante’s Inferno: A Comparative Study of Sandro Botticelli, Giovanni Stradano, and Federico Zuccaro. Cultural and Religious Studies, 4(8), 487.
Verdicchio, M. (2015). Irony and Desire in Dante’s” Inferno” 27. Italica, 285-297.
Sample Answer
Sample Answer
The Role of Stomach Bacteria in Cancer Development: Exploring the Human Microbiome
The human microbiome, particularly the gut microbiota, has gained increasing attention in cancer research due to its potential influence on tumorigenesis and cancer progression. The paper by Gao et al. published in the European Journal of Clinical Microbiology & Infectious Diseases in 2017 delves into the intricate relationship between gut microbiota and colorectal cancer, shedding light on the role of stomach bacteria in cancer development.
Literature Review
The gut microbiota plays a crucial role in maintaining host health through its involvement in various physiological processes, immune modulation, and metabolism. Disruption of the gut microbial equilibrium, known as dysbiosis, has been implicated in the pathogenesis of several diseases, including colorectal cancer. Gao et al.’s review discusses the interplay between gut microbiota composition, microbial metabolites, and host immune responses in the context of colorectal cancer.
Studies have demonstrated alterations in gut microbiota composition in individuals with colorectal cancer compared to healthy individuals, suggesting a potential link between specific bacterial species and cancer development. Furthermore, microbial dysbiosis has been associated with inflammation, genomic instability, and alterations in the tumor microenvironment, all of which can influence carcinogenesis and tumor progression.
Gaps in Knowledge
While current research has provided valuable insights into the association between gut microbiota and colorectal cancer, several gaps in knowledge warrant further investigation. These include elucidating the mechanistic pathways through which specific bacterial species promote tumorigenesis, identifying biomarkers for early cancer detection based on microbiota signatures, exploring the impact of dietary interventions on gut microbial composition and cancer risk, and developing targeted microbiota-based therapies for cancer prevention and treatment.
Research Question
Research Question: How do specific stomach bacteria contribute to the development and progression of colorectal cancer, and what are the implications for cancer prevention and treatment strategies?
Hypothesis: Dysbiosis-induced alterations in gut microbiota composition lead to inflammatory responses, metabolic changes, and immune dysregulation that promote colorectal cancer development. Targeted modulation of gut microbiota through probiotics, prebiotics, or fecal microbiota transplantation can mitigate cancer-promoting effects and enhance therapeutic outcomes in colorectal cancer patients.
This research question aligns with the growing interest in the role of the human microbiome in cancer pathogenesis and treatment. By investigating the mechanisms underlying the interaction between gut microbiota and colorectal cancer, we can uncover novel therapeutic targets and preventive strategies that leverage the microbiome’s influence on cancer development.
In conclusion, understanding the complex interplay between stomach bacteria and cancer development holds significant promise for advancing precision medicine approaches in oncology. By exploring the role of the human microbiome in colorectal cancer and translating research findings into clinical practice, we can pave the way for personalized interventions that target microbial factors to improve cancer outcomes.
Reference:
– Gao R, Gao Z, Huang L, Qin H. Gut microbiota and colorectal cancer. Eur J Clin Microbiol Infect Dis. 2017 Jan 7. doi: 10.1007/s10096-016-2881-8. Review. PubMed PMID: 28063002.
