3D cell printing of cancerous pancreatic tissue as a disease model

Focus on
: pancreas anatomy and physiology,Cells and Secretions of the Pancreatic Islets ,Pathophysiology (0.5 page)
: how to build a model of pancreatic using 3D printing (1.5 page)

3D printing of pancreatic tissue has emerged in the last decade as a feasible technique to recreate certain features of this organ (Kim et al 2020). Nonetheless, these efforts have been mainly focused on treating diabetes. Recently, Kim et al (2019) were able to engineer transplantable 3D pancreatic tissue using pancreas tissue decellularized extracellular matrix (pdECM) as a bioink to encapsulate islets. In parallel, Hakobyan et al (2020) utilized laser-assisted 3D printing to generate pancreatic spheroids arrays that could recapitulate some of the characteristics of pancreatic ductal carcinoma. These two approaches can be combined to reliably produce a disease model that mimics the development of pancreatic cancer, which will then serve diagnostic and therapeutic purposes.

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