1.What were Andrew Jackson’s policies on banking tariffs? How did they evolve? Do you think those policies helped or hurt the American economy? Why?
2.Why did the Democrats win the election of 1836 but lose the election of 1840?
Gaucher's infection happens inside people since they do not have the chemical glucocerebrosidase in the body, which is in charge of separating greasy substances called glucocerebroside. Thusly, a lot of greasy substances can develop and remain in the liver, spleen, lungs, bone marrow and mind due to the harmed and absence of glucocerebrosidase. Consequently, the ailment is likewise called glucocerebrosidase insufficiency. Any age gathering can be determined to have this sickness, yet examines demonstrate that there is a higher level of the illness in Eastern and Central European Jewish individuals. There are numerous kinds of Gaucher's malady. The principal shape is called non-neuronopathic Gaucher's illness since it doesn't target and harm the focal sensory system. The side effects are: Diminishing of bones Extraordinary bone agony and bone breaks Extended liver Extended spleen Low measures of solid red platelets Exorbitant weakness Powerlessness to wounding Low measures of blood platelets Yellow spots in the eyes Customary nosebleeds https://lh4.googleusercontent.com/L_C8g8O4Mhz8ku_AC2mnm_lIugwtAtwnXaywJ8KaxXrKS81D10a6ke6V4kDOm5Ds4ROGWx023hB8M3OtEoZEoE1eVCAy3KQkgtnjC-nYqf869BRdReH5jwFmIFuihB1ePghttps://lh3.googleusercontent.com/rtTft7qeHvqaGpxjhJr82VvvAHBzLLwWLGDj5Yv05L8bRz5-OZtz5MMlkSmZrDi_S9MZequrL-7y45rG-3uwkvzJFqIKtrl7zzq36iu8Fy8uFFNOYppU6kvysPBXEHaO-g The second kind of Gaucher's ailment is neuronopathic and it tends to be dangerous in light of the fact that it harms the focal sensory system. Children following three months of birth can be determined to have this type of Gaucher's ailment. Its side effects are like the non-neuronopathic frame, yet it likewise incorporates: Cerebrum issues, including dementia Serious resoluteness Seizures The last type of Gaucher's illness is called perinatal deadly and it is the most serious sort. Truth be told, most newborn children with perinatal deadly kick the bucket following a couple of long periods of birth. The manifestations recorded underneath: Broad swelling because of liquid gathering Dry and textured skin Genuine neurological issues https://lh3.googleusercontent.com/nN6Nvh30_EMx8llbGZC6uVg1KVeqyGrH2iwaKfmAzL2DZtmssNJoxgzzJmNmjCAMmjb63KUwbsXpfkxapyytLKWafeQ2UZ6jUrQV0gTM8LWOAixUpHzDMJGx8iTG8Zx3MQ Gaucher's illness creates because of transformations in the GBA quality. The GBA quality is in charge of making glucocerebrosidase proteins, which rearranges glucocerebroside atoms into sugars and littler fat particles. Nonetheless, transformations in the GBA quality effect the capacity of the chemicals to work appropriately. Therefore, the a lot of greasy substances cause organ disappointment. Patients can be determined to have Gaucher's sickness on account of a legacy design called autosomal passive. The guardians must be bearers of a Gaucher's hereditary change all together for the youngsters to have Gaucher's sickness. In any case, there is just a 25 percent chance that their tyke will be determined to have the infection. https://lh3.googleusercontent.com/xZxc39V63Caic0u2FViWGmd8oispCHGWX5MyQ8npoXdInyP0XNeZSHrQD7fpcltN3LTItUoNTLEh5HmRcbH0jTsdEHWq7RcHaeY8uMJNg5cb0Na7NSS3vHrAnW-E74lSaQ With the end goal to recognize and track the movement of Gaucher's sickness inside patients, a progression of determination and tests are utilized. Catalyst investigation utilizes blood tests to recognize a patient's dimensions of glucocerebrosidase. On the off chance that Gaucher's ailment was dynamic in the patient, there are low dimensions of glucocerebrosidase in the blood. Then again, bearers have catalyst levels between the influenced and unaffected individuals who are not transporters. Another test is known as the hereditary transformation investigation and it endeavors to discover changes in the qualities connect with Gaucher's malady. Be that as it may, not the majority of the hereditary transformations associated with Gaucher's infection have been distinguished; along these lines this test is utilized to help group which sort of Gaucher's illness patients have. With the end goal to gauge the movement of the sickness, double vitality X-beam absorptiometry (DXA), and attractive reverberation imaging (MRI) can likewise be utilized. DXA utilizes low vitality X-beams to gauge bone thickness, while MRI utilizes attractive fields and radio waves to make pictures of organs. X-ray can demonstrate organ amplification, for example, the spleen or liver. What's more, specialists perform pre-birth testing in pregnant ladies that are transporters of Gaucher's malady to test if Gaucher's ailment is dynamic in the hatchling. Specialists will investigate the amniotic liquid or tissues from the placenta to finish the pre-birth testing. https://lh6.googleusercontent.com/nZf5pJAeeen5e5_LclG2RIlifSbvRD7mFRicmsxFcEPsLWoZhQ24K2_ClTLjbod7HV94xJXqx0VTs4k_RqQ- - 6SACu2zapGhQmTzRJYwPWXxsFM_V8L1LBXNeSZjd3A97QGaucher's ailment can't be restored; it is just controlled or overseen. The sort of treatment given to patients shifts relying upon the sort and seriousness of Gaucher's malady and state of patients. One treatment given is the compound substitution treatment, where substitution catalysts in fluid substances are infused into the veins of patients like clockwork. This kind of treatment is compelling inside people with non-neuronopathic Gaucher's ailment. By and by, individuals may frequently encounter a hypersensitive response to the catalyst treatment. Another treatment technique accessible is the bone-marrow transplantation. This is a surgery that is utilized for serious instances of Gaucher's malady, where harmed blood-framing cells are evacuated and supplanted. In any case, this medicinal treatment isn't as normal as the compound substitution treatment since it has more dangers and risks. In conclusion, medicine can likewise be utilized to deal with Gaucher's infection. The oral medicine miglustat (Zavesca) is a powerful medication that limits the development of the greasy substances in non-neuronopathic Gaucher's infection. All things considered, the medicine can cause symptoms in the stomach related framework, for example, looseness of the bowels and, weight reduction. Besides, the medication can likewise meddle with sperm generation. In women, conception prevention is prompted while utilizing miglustat and for three months after they quit utilizing the medication. In December 2001, Genzyme, a Sanofi Company finished an examination to look at the adequacy of a medication, Cerezyme, in two diverse measurement sums in their patients with Gaucher's malady. The two guys and females ages 18 and more seasoned were qualified for study. By and by, just patients with sort 1, non-neuronopathic Gaucher's ailment were permitted to partake. There were numerous exploration focuses that taken an interest in the lab, incorporating eighteen in the United States, one in Canada, six in Europe, and one in Brazil. Amid the investigation, 90 members were randomized and set into two gatherings. The main gathering of individuals got their month to month portion of Cerezyme in two imbuements; one mixture for each two weeks (Q2). The second gathering of people got their month to month dose in one implantation consistently (Q4). The movement of the impacts of the medication on the Gaucher's sickness was checked by estimating the hemoglobin esteems and platelet tally of patients. Attractive reverberation imaging and PC tomography were likewise used to investigate any upgrades in the patient's liver and spleen conditions. Besides, analysts endeavored to recognize whether the adjustment in dose diminished the indications of patients, for example, exhaustion, weakness to wounding and yellow spots in the eyes. Genzyme trusted that patients who gotten one imbuement at regular intervals would demonstrate a more positive response towards their non-neuronopathic Gaucher's malady in light of the fact that there was a more extended timeframe in the middle of the month to month dose sessions of Q4. Thus, this could cause an insufficiency of all the supplanted glucocerebrosidase toward the month's end. On the other hand, Q2 would be more balanced out in light of the fact that the catalyst glucocerebroside would be supplanted at regular intervals. In principle, before every month's over, just 50% of the catalyst glucocerebroside would be insufficient. Also, the discoveries of the lab, showed in table one, demonstrated that 80.8% of the members of Q2 Cerezyme indicated clinical achievement, though there was just 63.2% of clinical accomplishment inside people utilizing Q4 Cerezyme. Henceforth, Q2 was a superior medication recurrence regarding wellbeing and adequacy. Q2 Cerezyme Q4 Cerezyme Number of Participants Analyzed 26 57 Number of members with Clinical Success 21 36 Extent of members with Clinical Success 80.8% 63.2% Table 1: Number of Participants with Clinical Success after the Completion of the Clinical Trial The outline above depicts the quantity of members that demonstrated enhancements in their Gaucher's illness in contrast with their condition before the clinical preliminary. For instance, a few members saw a decrease of side effects, for example, outrageous tiredness, wounding, yellow spots in the eyes, and nosebleeds. Too, there were a few enhancements in hemoglobin esteems, platelet check, and liver and spleen conditions. A comparative lab was directed to test the adequacy of two measurement sums in a catalyst substitution treatment on February 1, 2007. The worldwide claim to fame biopharmaceutical organization, Shire, needed to test VPRIV, a hydrolytic lysosomal glucocerebrosidase-particular chemical, that was utilized in long haul compound supplanting treatment for patients with sort 1 Gaucher's illness. The controlled variable of the investigation were the 45 and 60 U/kg measurements of VPRIV, otherwise called velaglucerase alfa (GA-GCB), given to patients with sort one Gaucher's malady. Shire likewise utilized arbitrary preliminaries to isolate the members into two gatherings that got the measurement each other week. By and by, one gathering got 45 U/kg and the other gathering gotten 60 U/kg of VPRIV. Ages two and more seasoned of the two sexual orientations were permitted to take an interest in the examination. The length of treatment for every patient was, where the primary patient enlisted into the examination on January 11, 2007, and the last patient took an interest in the exploration venture on April 8, 2008. The movement of the impacts of the medication on Gaucher's sickness was monit>GET ANSWER