Apoptosis is a very common mechanism of cell death that contributes to normal cell turnover, and there are many examples of the utility of apoptotic cell death. Apoptosis is also known as programmed cell death because the steps follow an orderly sequence (a death program), and tissue disruption, organ dysfunction, and inflammation are minimized.

Why is it important for cell death programs to exist? How do they contribute to normal physiology and the prevention of disease? What are the characteristics of Necrotic and Apoptotic Cell Death Pathways?

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Dante Alighieri played a critical role in the literature world through his poem Divine Comedy that was written in the 14th century. The poem contains Inferno, Purgatorio, and Paradiso. The Inferno is a description of the nine circles of torment that are found on the earth. It depicts the realms of the people that have gone against the spiritual values and who, instead, have chosen bestial appetite, violence, or fraud and malice. The nine circles of hell are limbo, lust, gluttony, greed and wrath. Others are heresy, violence, fraud, and treachery. The purpose of this paper is to examine the Dante’s Inferno in the perspective of its portrayal of God’s image and the justification of hell. 

In this epic poem, God is portrayed as a super being guilty of multiple weaknesses including being egotistic, unjust, and hypocritical. Dante, in this poem, depicts God as being more human than divine by challenging God’s omnipotence. Additionally, the manner in which Dante describes Hell is in full contradiction to the morals of God as written in the Bible. When god arranges Hell to flatter Himself, He commits egotism, a sin that is common among human beings (Cheney, 2016). The weakness is depicted in Limbo and on the Gate of Hell where, for instance, God sends those who do not worship Him to Hell. This implies that failure to worship Him is a sin.

God is also depicted as lacking justice in His actions thus removing the godly image. The injustice is portrayed by the manner in which the sodomites and opportunists are treated. The opportunists are subjected to banner chasing in their lives after death followed by being stung by insects and maggots. They are known to having done neither good nor bad during their lifetimes and, therefore, justice could have demanded that they be granted a neutral punishment having lived a neutral life. The sodomites are also punished unfairly by God when Brunetto Lattini is condemned to hell despite being a good leader (Babor, T. F., McGovern, T., & Robaina, K. (2017). While he commited sodomy, God chooses to ignore all the other good deeds that Brunetto did.

Finally, God is also portrayed as being hypocritical in His actions, a sin that further diminishes His godliness and makes Him more human. A case in point is when God condemns the sin of egotism and goes ahead to commit it repeatedly. Proverbs 29:23 states that “arrogance will bring your downfall, but if you are humble, you will be respected.” When Slattery condemns Dante’s human state as being weak, doubtful, and limited, he is proving God’s hypocrisy because He is also human (Verdicchio, 2015). The actions of God in Hell as portrayed by Dante are inconsistent with the Biblical literature. Both Dante and God are prone to making mistakes, something common among human beings thus making God more human.

To wrap it up, Dante portrays God is more human since He commits the same sins that humans commit: egotism, hypocrisy, and injustice. Hell is justified as being a destination for victims of the mistakes committed by God. The Hell is presented as being a totally different place as compared to what is written about it in the Bible. As a result, reading through the text gives an image of God who is prone to the very mistakes common to humans thus ripping Him off His lofty status of divine and, instead, making Him a mere human. Whether or not Dante did it intentionally is subject to debate but one thing is clear in the poem: the misconstrued notion of God is revealed to future generations.

 

References

Babor, T. F., McGovern, T., & Robaina, K. (2017). Dante’s inferno: Seven deadly sins in scientific publishing and how to avoid them. Addiction Science: A Guide for the Perplexed, 267.

Cheney, L. D. G. (2016). Illustrations for Dante’s Inferno: A Comparative Study of Sandro Botticelli, Giovanni Stradano, and Federico Zuccaro. Cultural and Religious Studies4(8), 487.

Verdicchio, M. (2015). Irony and Desire in Dante’s” Inferno” 27. Italica, 285-297.

This is for informational purposes only. For medical advice or diagnosis, consult a professional.

Importance of Cell Death Programs

  • Tissue Homeostasis: Apoptosis maintains a balance between cell proliferation and death, ensuring tissues don’t grow uncontrollably or shrink excessively.  
  • Development: It’s crucial during embryonic development, shaping organs and eliminating unwanted cells. For example, apoptosis carves out spaces between fingers and toes.  
  • Immune System Function: Eliminates self-reactive immune cells, preventing autoimmune diseases.

This is for informational purposes only. For medical advice or diagnosis, consult a professional.

Importance of Cell Death Programs

  • Tissue Homeostasis: Apoptosis maintains a balance between cell proliferation and death, ensuring tissues don’t grow uncontrollably or shrink excessively.  
  • Development: It’s crucial during embryonic development, shaping organs and eliminating unwanted cells. For example, apoptosis carves out spaces between fingers and toes.  
  • Immune System Function: Eliminates self-reactive immune cells, preventing autoimmune diseases.
  • Disease Prevention: Removes damaged or infected cells, preventing the spread of disease and the development of cancer.  

Apoptosis vs. Necrosis

Feature Apoptosis (Programmed Cell Death) Necrosis (Accidental Cell Death)
Energy Requirement Requires energy (ATP) Does not require energy
Cell Membrane Integrity Maintained initially, then blebbing occurs Disrupted early, leading to cell swelling and lysis
Inflammation Minimal or no inflammation Significant inflammation
DNA Degradation

Organized and controlled fragmentation Random DNA degradation
Cell Size Cell shrinkage (cell shrinkage) Cell swelling (oncosis)

Apoptosis Pathways

  • Intrinsic Pathway (Mitochondrial Pathway):
    • Triggered by internal cellular stress (e.g., DNA damage, oxidative stress).  
    • Involves release of cytochrome c from mitochondria, activating caspases (a family of proteases).  
  • Extrinsic Pathway (Death Receptor Pathway):
    • Triggered by external signals, such as binding of death ligands to cell surface receptors.  
    • Also involves activation of caspases.  

In Summary

Apoptosis is a vital physiological process that plays a crucial role in maintaining tissue homeostasis, preventing disease, and ensuring proper development. Its controlled nature minimizes damage to surrounding tissues and prevents the uncontrolled inflammation associated with necrosis. Understanding the mechanisms of apoptosis is essential for developing therapies for various diseases, including cancer and neurodegenerative disorders.  

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