Atez Home Health Agency, change the collection of revenues percent to 45% in the month billing occured, in the next month 25%, and 15% in the following month. No other changes made to the assignment. Determine during which months Aztec can invest surplus funds and which months it might need to borrow.
will ensure high efficiency of the drug and minimize the side effects, especially when dealing with drugs that are supposed to kill cancer cells but can also kill healthy cells when delivered to them. Controlled drug release can decrease or even prevent its side effects. The advantages of using nanoparticles for drug delivery applications rise from their three main basic properties. First, nanoparticles, because of their small size, can penetrate through smaller capillaries, which could allow efficient drug accumulation at the target sites [42, 43]. Second, the use of biodegradable materials for nanoparticle preparation can allow sustained drug release within the target site over a period of days or even weeks [44-46]. Third, the nanoparticle surface can be adapted to modify biodistribution of drugs or can be conjugated to a ligand to attain target-specific drug delivery [47, 48]. The advantages of using nanoparticles as drug delivery system include: (1) stable dosage forms of drugs which are either unstable [49, 50] or have unacceptably low bioavailability in non-nanoparticulate dosage forms[51, 52] ; (2) they control and sustain release of the drug during the transportation and at the site of localization , varying organ distribution of the drug and subsequent clearance of the drug so as to achieve increase in drug therapeutic efficacy and reduction in side effects ; (3) site-specific targeting can be achieved by attaching targeting ligands to surface of particles or use of magnetic guidance [55, 56]; (4) controlled release and particle degradation characteristics can be readily modulated by the choice of matrix constituents. Due to biodegradability, pH, ion and/or temperature sensibility of materials they allow sustained drug release within the target site over a period of days or weeks [40, 57]; (5) they can pass through smallest capillary vessels and be taken up by cells, which allow efficient drug accumulation at the target sites [58-60] because of their ultra-tiny volume and avoiding rapid clearance by phagocytes so their duration in blood stream is deeply prolonged. This is especially needed for tumors which are characterized by extensive angiogenesis, defective vascular architecture, impaired lymphatic drainage and increased production of permeability factors. This phenomenon is known as the enhanced permeability and retention effect [13, 57, 61]; (6) increased active agent surface area results in a faster dissolution of the >GET ANSWER