I. What are T cells and their importance to the immune system?
- What is the role of dendritic cells in the body’s normal immune response?
- How did the researchers mimic and improve the dendritic cells’ stimulatory behavior?
- What are the two major challenges in mounting an immune response to cancer?
- What are the roles of the MHC protein molecule, antigens and the ligand-protein molecule in telling the T cell to attack a cancer cell?
- Describe howCÅR T cells were developed d including the use of HIV particles.
- Why was the CD19 surface protein an attractive target for CAR T cell therapy?
- Why can CAR T cells be described as a “living drug”?
- Why does CAR T cell therapy not work for all leukemia patients?
- What are the problems in developing an immune-based treatment for solid tumors and how might these problems be overcome?
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