DNA tumor virus researchers characterized the DNA tumor virus genes and proteins that induced cancer phenotype (or ‘transformed’ the infected cells). Although the main cancer-causing proteins from different virus families (adenovirus, papilloma virus, and polyoma virus) did not closely resemble each other (or any cellular proteins), they had a common structural motif that was used to bind and inactivate some really important cellular proteins. please find literature that support any of your claims
a) What category of proteins do the main DNA tumor virus oncoproteins bind?
b) Give two examples of the proteins that DNA Tumor Virus oncoproteins bind
c) How does DNA Tumor Virus oncoprotein binding to the two cellular targets contribute to cell transformation
Sample Solution
