Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following:
Atenolol 12.5 mg daily
Doxazosin 8 mg daily
Hydralazine 10 mg qid
Sertraline 25 mg daily
Simvastatin 80 mg daily
Review the above case study.
Select one the following factors: genetics, gender, ethnicity, age, or behavior factors.
Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.
Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.
Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.
Write a 2- to 3-page paper that addresses the following:
Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.
Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples.
Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements.
The world of Macbeth explores the destructive nature of power and ambition through the collapse of individual identity and the Christian emphasis on the moral hierarchy. Published in 1623, nearly twenty years after it was first performed, Macbeth was written shortly after James VI of Scotland ascended the English throne, and Shakespeare’s play clearly supports his divine right to the throne. Shakespeare was inspired by Raphael Holinshed’s Chronicle of the reigns of Duncan and Macbeth (A.D. 1034-57), but the invention of the framework of the witches who tempt both Banquo and Macbeth with prophecies of greatness are his own. A story of witchcraft, murder and vengeance, Macbeth can be read as a morality play which warns against the dangers of ambitious power. Clearly, Macbeth is a figure whose ambition and hubris result in his fall from power, echoing the biblical story of the fall from grace; however, the play also expresses a profound fear of feminine power as subversive and destructive. The very text of Macbeth itself reflects the single-minded ambition of its main character. With only 2,100 lines, Macbeth is one of Shakespeare’s shortest plays, and with the exception of such characters as the porter, is devoid of the subplots which characterise Shakespearean tragedies. Coleridge has noted that the play begins at an aggressive pace with Hamlet‘s ‘gradual ascent from the simplest forms of conversation to the language of impassioned intellect’, and Bradley follows by describing the beginning of the play as one in which ‘the action burst into wild life’. Shakespeare’s typical tragic worldview represents a complex human world of infinite variety. Macbeth, in contrast, is sparse and single-minded because it is a symbolic play which resorts to soliloquy and symbolic locales to echo the dichotomous world of the Christian morality plays. The focus of Macbeth, like that of Shakespeare’s famous tragedy Richard III, is an egotistical man with measureless will power who murders his way to the crown and, in doing so, alienates himself from the very world which he wishes to rule. It is commonly said by Shakespearean critics that Macbeth’s tragic flaw is ambition, and he himself admits that he has no drive but ‘vaulting ambition’, but it is ambition without reason or application. He does not, like Shakespeare’s Tamburlaine, believe it to be ‘passing brave’ to be sovereign king and ride in triumph through his kingdom, or even desire the power which he would then have over his comrades. Indeed, the sole drive behind Macbeth’s ambition seems to be the act of competition itself, which is clearly shown by his celebrated success on the battlefield. The audience is introduced to Macbeth through the description by the Sergeant in Act I Scene II. The description of the battle scene and Macbeth’s eruptive entrance into the horde of ‘kerns and gallowglasses’ reveals Macbeth’s ambition and the violence of his power. Brave Macbeth – well he deserves that name –>GET ANSWER