In this section, provide one word to describe each section of your proposed PICOT question
Section 2: Write your PICOT question below using the words listed above.
Section 3: Use your PICOT to develop a formalized statement. Use the examples below to help formulate statement.
For an intervention/therapy:
In (P), what is the effect of (I) on (O) compared with _(C) within __ (T)?
Are _ (P) who have _ (I) at (Increased/decreased) risk for/of_______ (O) compared with _ (P) with/without (C) over (T)?
Diagnosis or diagnostic test:
Are (is) (I) more accurate in diagnosing (P) compared with (C) for __ (O)?
For (P) does the use of (I) reduce the future risk of (O) compared with _ (C)?
Does _ (I) influence (O) in patients who have (P) over __ (T)?
How do (P) diagnosed with (I) perceive (O) during __ (T)?
ReferencesCreswell, J. W. (2003). Research design: Qualitative, quantitative, and mixed methods approaches. Thousand Oaks, CA: Sage Publications.
Melnyk, B. M., & Fineout-Overholt, E. (2010). Evidence-based practice in nursing and healthcare. New York: Lippincott Williams & Wilkins.
Indonesia (22%). Diagnosis Prompt and accurate diagnosis is critical to the effective management of malaria. Malaria diagnosis involves identifying malaria parasites or antigens/products in patient blood. Various diagnostic methods for malaria parasite identification includes clinical diagnosis, microscopy, QBC method, rapid diagnostic test kits, serological test, molecular methods like PCR, flow cytometry, LAMP, microarray, mass spectrometry. Treatments AS+SP, is recommended for all uncomplicated Pf case in the county except North eastern (NE) states. In NE states, the combination of Artemether-lumefantrine (AL) is recommended). Drug resistance According to WHO, resistance to antimalarial drugs can be defined as ‘the ability of a parasite strain to survive and/or to multiply despite the administration and absorption of a drug given in doses equal to, or higher than, those usually recommended, but within the limits of tolerance of the subject’ (WHO). Chloroquine CQ resistance is associated with a decrease accumulation of CQ concentration in the food vacuole of parasites, which is the site of action for C (Fidock et al., 2000.). The substitution of lysine to threonine (K76T) at codon 76 of the pfcrt gene is associated with in vivo and in vitro CQ resistance in Africa, South America, and Southeast Asia (Anvikar et al., 2012; Garcia et al., 2004; Ojurongbe. et al., 2007). Sulphadoxine-pyrimethamine(SP) SDX and PYR is inhibiting to the DHPS and DHFR enzymes, respectively, specific point mutations in Pfdhps & Pfdhfr gene encoding these enzymes lead to a lower binding affinity for sulphadoxin>GET ANSWER