The collection of evidence is an activity that occurs with an endgame in mind. For example, law enforcement professionals collect evidence to support a decision to charge those accused of criminal activity. Similarly, evidence-based healthcare practitioners collect evidence to support decisions in pursuit of specific healthcare outcomes.
identify an issue or opportunity for change within your healthcare organization and propose an idea for a change in practice supported by an EBP approach.
Reflect on the four peer-reviewed articles you critically appraised in Module 4, related to your clinical topic of interest and PICOT.
Reflect on your current healthcare organization and think about potential opportunities for evidence-based change, using your topic of interest and PICOT as the basis for your reflection.
Consider the best method of disseminating the results of your presentation to an audience.
The Assignment: (Evidence-Based Project)
Part 4: Recommending an Evidence-Based Practice Change
Create an 8- to 9-slide narrated PowerPoint presentation in which you do the following:
Briefly describe your healthcare organization, including its culture and readiness for change. (You may opt to keep various elements of this anonymous, such as your company name.)
Describe the current problem or opportunity for change. Include in this description the circumstances surrounding the need for change, the scope of the issue, the stakeholders involved, and the risks associated with change implementation in general.
Propose an evidence-based idea for a change in practice using an EBP approach to decision making. Note that you may find further research needs to be conducted if sufficient evidence is not discovered.
Describe your plan for knowledge transfer of this change, including knowledge creation, dissemination, and organizational adoption and implementation.
Explain how you would disseminate the results of your project to an audience. Provide a rationale for why you selected this dissemination strategy.
Thus far, most of the suggested gold nanostructures have been applied in the treatment of tumours via photothermal therapy. The gold/gold sulfide nanoparticles prepared in the method described by Ren and Chow were studied as a method of drug delivery, for the anti-cancer drug cisplatin Traditionally, drugs would be delivered via chemotherapy, however this method is least convenient to the patient. There is no selectivity as with photothermal therapy, and so healthy cells can also be damaged, although because malignant cells have “abnormal” properties, they are more likely to be affected by the drug.2 Loading the drug onto a carrier presents a level of selectivity, so that the drug will only be released once in the region of the target cells, and thus only the malignant cells are destroyed. The release of a drug upon heating can be defined as “photodynamic therapy”. In order to determine how effective the gold/gold-sulfide nanoparticles were at releasing cisplatin, the nanoparticles were suspended in 2mL of water and irradiated with light from a 1064nm Nd:YAG laser for one hour. Throughout this hour, samples of the gold/gold-sulfide nanoparticle solution were taken and analysed by HPLC in order to analyse how much cisplatin had been released, in addition to samples which had not been irradiated with the laser. It can be seen from the figure above that the nanoparticles treated with laser radiation were the most effective at releasing cis-platin, with approximately 90% of cisplatin released within the first 10 minutes. The nanoparticles which had been heated to 40C demonstrated some photodynamic effect, with approximately 40% of cisplatin released over the course of an hour. Those which had not been treated with laser light or heat (control) showed virtually no release of cis-platin. This study has shown the potential for gold/gold-sulfide nanoparticles as drug delivery systems, due to the effective release of cis-platin under NIR light, however this study was conducted entirely in vitro and so further testing in vivo would be suggested in order to fully predict how effectively cisplatin can be delivered this way, inside the body. The Fe3O4-polymer-gold shell nanoparticles proposed by Wang et al have the potential to be applied in both the diagnosis and treatment of cancer tumours, however no physical studies were carried out involving such an application, and so there is a disadvantage that any application suggested by this literature is entirely speculative. MRI is a method of diagnostic imaging, with the pictures produced by the process being either T1 weighted, T2 weighted, or proton density weighted, and tumours are visualised as dark areas in T1 weighted images.33 Metal oxide nanoparticles, such as the Fe3O4-polymer-gold shell nanoparticles, can act as a contrasting agent in>GET ANSWER