What are the key benefits and dangers of the development of Big Data and its approaches for the national security of democracies?
Mice are another model figure that has been widely studied, due to their reproductive and genetic similarity to humans. BPA is an environmental endocrine disruptor (ED) which is a synthetic chemical that has resemblance toward natural hormones which affect development and fertility. Genes that are haploid undergo epigenetic resetting between generation and susceptible to environmental insults are called imprinted genes.3 The parental-specific methylation at different methylated regions are sustained in somatic cells throughout the lifespan of the individual, but reset specifically between generations in the germ line. In this experiment, epigenetic divergence caused by BPA exposure to imprinted genes was screened for. The effects of BPA on the preservation of imprinted gene expression were measured by a multiplex allele specific assay was generated. Mimicking or blocking endocrine actions are a few ways in which endocrine disruptors can affect methylation patterns and gene expression of DNA.13 It is hypothesized that the two parental chromosomes epigenetic reciprocal can be altered by hormone-like chemicals, gene expression and DNA methylation. 3,13 Measuring 39 imprinted transcripts for allele specific expression (using multiplex SNuPE) and characterization of the imprinted gene expression on mouse chromosome 7 were performed.13,3 Treated with BPA as well as a control oil were pregnant mice 8.5 to 12.5-days post conception (dpc). On the 13.5 dpc, yolk sac, placenta, head, body, heart, liver, lung, stomach, and intestines of the embryos that were treated were isolated to obtain RNA.3 When exposure to BPA specifically at different parts of development the correct expression of imprinted genes is disturbed as shown through the data. BPA at 0.02 mg exposed to fetus caused decrease sperm production (Fig. 6). Low exposure of BPA affects certain imprinted genes, while high exposure to BPA affects other imprinted genes in “non-substantial” ways.3 In high dose studies there are effects which are not seen physically but appear due to low dose encounters of BPA , the dosage amount depends on whether the response is hindered or not.13 This is important data to conclude from the experiment because in human serum the average levels of BPA are 0.5 to 10 n>GET ANSWER