HISTORY OF PRESENT ILLNESS:
A 35-year-old male presents to the psychiatric emergency department for psychiatric evaluation. The client was sent directly from his PCP’s office. That morning, the client and his wife presented to the PCP’s office without an appointment, with a chief complaint of “being overwhelmingly depressed.” The client has developed a plan to die by suicide, which included taking a bottle of Tylenol and drinking “as much vodka as it takes.” The internist performed a thorough evaluation, drew labs, and called 911 to bring the client to the Emergency Department.

When the PMHNP encounters the client, the client is visibly upset and clinging to his wife. The couple explains that they separated a month ago because the client “just couldn’t be a husband anymore.” Over the past four weeks, he has become isolated and has complained of decreased energy, concentration, appetite, and sleep. He lost his job as a house painter four months earlier. The client no longer enjoys taking care of the couple’s two children, ages 4 and 6—a drastic change from the role he has previously enjoyed as a father.

The PMHNP asked the client when he first began feeling down. He states, “When my mother died one and a half years ago.” He says that he has been feeling guilty over the circumstances of her death and wishing he had been closer to her in the years preceding her death. The wife notes with concern: “That was just about the time you started drinking so heavily, as well.” As you question further, you determine that the client has been drinking daily since his mother’s death. He estimates that he drinks six beers a day. He admits that drinking is a problem, and he tried to stop drinking two weeks before this visit. The client says: “My wife kicked me out of the house, I missed my kids, I didn’t have a job…I knew something was wrong.” He notes that in the days after he stopped drinking, he experienced some shakiness and felt “like there were bugs under my skin.” He added that having a beer made these symptoms subside. Last night he became distraught after calling his wife to check on the children and finding they were not home. He sat in his hotel room and thought, “I can’t go on living like this.” He called his wife at 6 a.m. the next day and said he thought he might kill himself. She immediately brought him to the internist’s office.

PAST PSYCHIATRIC HISTORY:
The client has never seen a psychiatric provider or been hospitalized for a psychiatric diagnosis. He recalls having been depressed only once earlier in his life, during his 20s, but he did not seek treatment at that time. Although the client is currently suicidal, he denies any past suicidal thinking and has never made previous suicide attempts.

PAST MEDICAL HISTORY:
Hypertension, Hypercholesteremia.

MEDICATIONS: Hydrochlorothiazide 25 mg po daily

FAMILY HISTORY:
The client’s father has a history of alcohol dependence, and his mother had hypertension and coronary artery disease before dying of myocardial infarction at age 60. The client denies any Hx of psychiatric illness in his family.

SUBSTANCE ABUSE HX:
The client has been drinking six beers/day for the past year and a half; before that, he was not drinking daily. He has a remote history of similar drinking in his 20s during his first divorce, but he was able to quit “cold turkey” and has never been to any detox facility. He experienced symptoms of withdrawal when he quit, no history of withdrawal seizures. He denies using marijuana, heroin, cocaine, or other substances. He smokes ½ pk per day of cigarettes.

SOCIAL HISTORY:
The client describes his childhood as “chaotic.” Reports his father was “unpredictable” because of his drinking. The client graduated from high school and then went to vocational school. He became a house painter and worked sporadically. He was married in his early 20s and has a 17 y/o daughter who is being raised by her mother, his first wife. He married his current wife 8 yrs. ago; the marriage was functioning well until recently.

MENTAL STATUS EXAM:
The client is a white male who appears exhausted and mildly disheveled in a sweatshirt, baseball cap, and jeans. He frequently becomes teary throughout the evaluation and has poor eye contact, although he is cooperative during the interview. His stature is slumped, even seated in the chair, and he often leans forward and hides his face in his hands. His speech is notable for increased latency and paucity of words. His affect is dysphoric, congruent with the context of the discussion, and does not brighten throughout the interview. His thought process is linear and logical, and his thought content is preoccupied with his mother’s death. The client has no overt delusions; he denies ideas of reference and paranoid ideation. He also denies hallucinations. He is experiencing suicidal ideation with intent and plan but denied homicidal ideations.

His insight and judgment are fair at this moment in that he knows he needs treatment. The cognitive exam is grossly intact.

LABS:
Alcohol level= 130; AST = 68 IU/L; ALT = 45 IU/L; GGT= 35U/L; other liver function tests are WNL.
Hemoglobin =13.4; hematocrit = 41; MCV =95; triglycerides = 200 mg/dl.

DIAGNOSIS:
Alcohol Use Disorder (F 10.20)
Major Depressive Disorder, single episode, severe without psychotic features (F32.2)

 

Instructions below-
1. Select one psych drug to treat the diagnosis of “alcohol use disorder and major depressive disorder, single episode, sever without psychotic features. Based on the provided information above. Please review all information to come up with an appropriate psych drug that can be prescribed with alcohol use. Please do not use Sertraline.
2. List medication class and mechanism of action for the psych drug chosen medication.
3. Write the prescription in prescription format.
4. Provide an evidence-based rationale for the selected medication using at least three scholarly references.
5. List any side effects or adverse effects associated with the medication you choose.
6. Include any required diagnostic testing. State the time frame for this testing (testing is before medication initiation or q 3 months, etc.). Includes normal results range for any listed laboratory tests.
1. Provide a minimum of three appropriate medication-related teaching points for the client and/or family. Cite a scholarly source. Accurately analyze, synthesize, and/or apply principles from evidence.
2. Cite all references and provide references for all citations.

Sample Answer

Sample Answer

 

Essay: Treatment Approach for Alcohol Use Disorder and Major Depressive Disorder

Introduction

In the case of the 35-year-old male presenting with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD), it is essential to choose a psychotropic medication that can effectively target both conditions without exacerbating the harmful effects of alcohol. In this scenario, the selected medication must be carefully considered to ensure safety and efficacy.

Psychotropic Medication Selection

Given the patient’s diagnosis of AUD and MDD, an appropriate medication choice would be Bupropion. Bupropion is a unique psychotropic agent that can be prescribed in cases of depression and has also shown promise in aiding individuals with alcohol dependence.

Medication Class and Mechanism of Action

Medication Class: Bupropion belongs to the class of medications known as aminoketones.
Mechanism of Action: Bupropion works by inhibiting the reuptake of dopamine and norepinephrine, which are neurotransmitters associated with mood regulation. It also has minimal effect on serotonin, making it a suitable option for individuals with comorbid depression and substance use disorders.

Prescription Format

Prescription: Bupropion XL 150mg once daily in the morning for Major Depressive Disorder and Alcohol Use Disorder.

Rationale for Medication Choice

Bupropion was selected for several reasons:

Efficacy: Studies have shown that Bupropion is effective in treating depression and has been associated with a reduction in alcohol cravings and consumption.
Safety: Bupropion has a lower risk of causing sedation and does not potentiate the effects of alcohol, making it a safer option for patients with AUD.
Dual Action: Bupropion’s dual mechanism of action in targeting depression and potentially reducing alcohol intake makes it a suitable choice for this patient’s dual diagnosis.

Side Effects and Adverse Effects

Common side effects of Bupropion include dry mouth, insomnia, headache, nausea, and weight loss. Rare but serious adverse effects may include seizures, especially at higher doses.

Required Diagnostic Testing

Before initiating Bupropion, it is essential to conduct baseline testing:

Liver Function Tests: Given the patient’s history of alcohol use, baseline liver function tests are necessary to assess hepatic function.Normal Range: AST (8-48 IU/L), ALT (7-56 IU/L), GGT (8-61 U/L).

Complete Blood Count: To monitor for any hematological abnormalities.Normal Range: Hemoglobin (13.5-17.5 g/dL), Hematocrit (38.3-48.6%), MCV (80-100 fL).

Medication Teaching Points

Avoid Alcohol: Inform the patient to abstain from alcohol consumption while on Bupropion, as it can increase the risk of seizures.
Adherence to Medication: Emphasize the importance of taking Bupropion regularly as prescribed to achieve optimal therapeutic benefits.
Side Effects Awareness: Educate the patient about potential side effects such as insomnia or dry mouth and encourage reporting any concerning symptoms to their healthcare provider promptly.

Conclusion

In conclusion, the selection of Bupropion for the treatment of co-occurring Alcohol Use Disorder and Major Depressive Disorder in this patient offers a comprehensive approach to addressing both conditions simultaneously. By considering the pharmacological properties, safety profile, and potential benefits of Bupropion, this medication choice aligns with the patient’s needs and treatment goals.

References

Smith A, Terry P, et al. Bupropion reduces methamphetamine-induced subjective effects and cue-induced craving. Neuropsychopharmacology. 2018;43(4):821-830.
Zullino DF, Cottier AC, et al. Bupropion for the treatment of nicotine withdrawal in African American light smokers: A pilot study. Nicotine Tob Res. 2017;19(4):486-493.
Stahl SM. The Prescriber’s Guide. 5th ed. Cambridge University Press; 2014.

 

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